Copper-catalyzed asymmetric 1,4-conjugate addition of Grignard reagents to linear α,β,γ,δ-unsaturated ketones.
نویسندگان
چکیده
A highly regioselective and enantioselective copper-catalyzed 1,4-conjugate addition of Grignard reagents to linear α,β,γ,δ-unsaturated ketones was developed. The 1,4-addition products were obtained regioselectively in high yields with up to 98% ee.
منابع مشابه
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ورودعنوان ژورنال:
- Chemical communications
دوره 49 46 شماره
صفحات -
تاریخ انتشار 2013